A prospective study on thyroid functions in chronic kidney disease patients: In tertiary care centre
Author(s): Dr. Dhulipalla Harika and Dr. Sindhu Mandala
Abstract: Background and Objectives: Unusual thyroid function tests are frequent in chronic kidney disease patients. The kidneys play an important role in thyroid hormone metabolism by converting T4 to T3 (the active metabolite). Low plasma free T3 in ESRD is a marker of inflammation and endothelial activation, and it has been linked to an increased risk of death from any cause. The present study has been conducted to look for biochemical abnormalities in thyroid function tests in chronic kidney disease, as well as to correlate the severity of CKD and changes in thyroid indices.
Methods: In a cross-sectional study, thyroid function tests [TT3, TT4, FT4, TSH] were estimated by CLIA in 60 patients of chronic kidney disease who were in various stages. Symptoms of hypothyroidism, thyroid hormone abnormalities and CKD stage were analyzed using Chi-square test and ANOVA tests.
Results: Among the mean age was 48.8 ± 12.2 years, of which 38 were male and 22 females. The mean value of TT3 in CKD stage 3, 4, 5 were 1.01±0.39; 1.05± 0.6; 0.95±1.09 µg/mL respectively. (p= 0.02 Significant). The mean value of TT4 in CKD stage 3, 4, 5 were 6.3± 2.4; 5.5± 1.5; 5.11 ± 1.01 µIU/ml, respectively. (p=0.71 Not significant).
Conclusions: Total T3 and total T4 levels were found to decrease progressively as the stage of CKD increased. There was no statistically significant relationship between TT4 and CKD stage. The prevalence of thyroid dysfunction and the stage of chronic kidney disease were found to be significantly related. The severity of renal failure increases the prevalence of thyroid hormone abnormalities; the levels of thyroid profile, i.e. T3, T4, and TSH, decrease as the severity of renal failure increases. Thyroid hormone abnormalities could represent a risk factor for cardiovascular disease and might also be implicated in kidney disease progression.
DOI: 10.22271/27069567.2021.v3.i2f.275Pages: 372-377 | Views: 830 | Downloads: 371Download Full Article: Click Here
How to cite this article:
Dr. Dhulipalla Harika, Dr. Sindhu Mandala.
A prospective study on thyroid functions in chronic kidney disease patients: In tertiary care centre. Int J Adv Res Med 2021;3(2):372-377. DOI:
10.22271/27069567.2021.v3.i2f.275
